A Role for Phospholipase Cg-mediated Signaling in Tumor Cell Invasion 1

  title={A Role for Phospholipase Cg-mediated Signaling in Tumor Cell Invasion 1},
  author={Jareer N Kassis and Jason Moellinger and Han Lo and Norman M. Greenberg and Hyung-gyoon Kim and Alan Wells},
The invasive and metastatic transformation of cancers often results in death. However, the mechanisms that promote this transformation remain unclear. Two closely related receptors, the epidermal growth factor receptor (EGFR) and ErbB2, are overexpressed in a significant percentage of breast and prostate carcinomas, among others, with this up-regulated signaling correlating with tumor progression. Previous studies in our laboratory have demonstrated that an EGFR-phospholipase C (PLC)g-mediated… CONTINUE READING
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