A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration

@article{Luca2008ARF,
  title={A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration},
  author={Gabriele De Luca and Mar{\'i}a Teresa Russo and Paolo Degan and Cecilia Tiveron and Andrea Zijno and Ettore Meccia and Ilenia Ventura and Elisabetta Mattei and Yusaku Nakabeppu and Marco Crescenzi and Rita Pepponi and Antonella P{\`e}zzola and Patrizia Popoli and Margherita Bignami},
  journal={PLoS Genetics},
  year={2008},
  volume={4},
  pages={4411 - 4}
}
Several human neurodegenerative disorders are characterized by the accumulation of 8-oxo-7,8-dihydroguanine (8-oxodG) in the DNA of affected neurons. This can occur either through direct oxidation of DNA guanine or via incorporation of the oxidized nucleotide during replication. Hydrolases that degrade oxidized purine nucleoside triphosphates normally minimize this incorporation. hMTH1 is the major human hydrolase. It degrades both 8-oxodGTP and 8-oxoGTP to the corresponding monophosphates. To… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 43 REFERENCES

Similar Papers

Loading similar papers…