A Role for Nogo Receptor in Macrophage Clearance from Injured Peripheral Nerve

@article{Fry2007ARF,
  title={A Role for Nogo Receptor in Macrophage Clearance from Injured Peripheral Nerve},
  author={Elizabeth Jane Fry and Carole Ho and SymonsJ. David},
  journal={Neuron},
  year={2007},
  volume={53},
  pages={649-662}
}
We report a role for Nogo receptors (NgRs) in macrophage efflux from sites of inflammation in peripheral nerve. Increasing numbers of macrophages in crushed rat sciatic nerves express NgR1 and NgR2 on the cell surface in the first week after injury. These macrophages show reduced binding to myelin and MAG in vitro, which is reversed by NgR siRNA knockdown and by inhibiting Rho-associated kinase. Fourteen days after sciatic nerve crush, regenerating nerves with newly synthesized myelin have… CONTINUE READING

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