A Role for NADPH Oxidase in Antigen Presentation

  title={A Role for NADPH Oxidase in Antigen Presentation},
  author={Gail J Gardiner and Sarah N. Deffit and Shawna McLetchie and Liliana P{\'e}rez and Crystal C. Walline and Janice S Blum},
  booktitle={Front. Immunol.},
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expressed in phagocytes is a multi-subunit enzyme complex that generates superoxide (O2 (.-)). This radical is an important precursor of hydrogen peroxide (H2O2) and other reactive oxygen species needed for microbicidal activity during innate immune responses. Inherited defects in NADPH oxidase give rise to chronic granulomatous disease (CGD), a primary immunodeficiency characterized by recurrent infections and granulomatous… CONTINUE READING
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