A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination

@article{Martomo2004ARF,
  title={A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination},
  author={Stella A. Martomo and William Yang and Patricia J Gearhart},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={200},
  pages={61 - 68}
}
Somatic hypermutation is initiated by activation-induced cytidine deaminase (AID), and occurs in several kilobases of DNA around rearranged immunoglobulin variable (V) genes and switch (S) sites before constant genes. AID deaminates cytosine to uracil, which can produce mutations of C:G nucleotide pairs, and the mismatch repair protein Msh2 participates in generating substitutions of downstream A:T pairs. Msh2 is always found as a heterodimer with either Msh3 or Msh6, so it is important to know… CONTINUE READING

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