A Role for Mac-1 (CDIIb/CD18) in Immune Complex–stimulated Neutrophil Function In Vivo: Mac-1 Deficiency Abrogates Sustained Fcγ Receptor–dependent Neutrophil Adhesion and Complement-dependent Proteinuria in Acute Glomerulonephritis

@article{Tang1997ARF,
  title={A Role for Mac-1 (CDIIb/CD18) in Immune Complex–stimulated Neutrophil Function In Vivo: Mac-1  Deficiency Abrogates Sustained Fcγ Receptor–dependent  Neutrophil Adhesion and Complement-dependent  Proteinuria in Acute Glomerulonephritis },
  author={Tao Tang and Alexander R. Rosenkranz and Karel J. M. Assmann and Michael J. Goodman and Jos{\'e}-Carlos Gutierrez-Ramos and Michael C Carroll and Ramzi S. Cotran and Tanya Norton Mayadas},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={1853 - 1863}
}
Mac-1 (alphambeta2), a leukocyte adhesion receptor, has been shown in vitro to functionally interact with Fcgamma receptors to facilitate immune complex (IC)-stimulated polymorphonuclear neutrophil (PMN) functions. To investigate the relevance of Mac-1-FcgammaR interactions in IC-mediated injury in vivo, we induced a model of Fc-dependent anti-glomerular basement membrane (GBM) nephritis in wild-type and Mac-1-deficient mice by the intravenous injection of anti-GBM antibody. The initial… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

A novel role for the b 2 integrin , CD 11 b / CD 18 , in neutrophil apoptosis : a homeostatic mechanism in inflammation

  • A. Coxon, P. Rieu, +4 authors T. N. Mayadas
  • Immunity .
  • 1996

A novel role for the {32 integrin, CD 1 lb /C D 18, in neutrophil apoptosis: a homeostatic mechanism in inflammation

  • A. Coxon, P. Rieu, +4 authors T.N
  • Mayadas
  • 1996

CR 3 ( a m b 2 ; CD 11 b / CD 18 ) restores IgG - dependent phagocytosis in transfectants expressing a phagocytosis - defective Fc g RIIA ( CD 32 ) tail - minus mutant

  • M.-J. Zhou, H. Poo, R. F. Todd, H. R. Petty
  • J . Immunol .
  • 1996

CR3(amP2; CD1 lb / CD 18) restores IgG-dependent phagocytosis in transfectants expressing a phagocytosis-defective FcyRIIA (CD32) tailminus mutant

  • R. G. Worth, L. Mayo-Bond, J.G.J. van de Winkel, R. F. Todd, H. R. Petty
  • J. Immunol
  • 1996

Similar Papers

Loading similar papers…