A Role for Mac-1 (CDIIb/CD18) in Immune Complex–stimulated Neutrophil Function In Vivo: Mac-1 Deficiency Abrogates Sustained Fcγ Receptor–dependent Neutrophil Adhesion and Complement-dependent Proteinuria in Acute Glomerulonephritis

@article{Tang1997ARF,
  title={A Role for Mac-1 (CDIIb/CD18) in Immune Complex–stimulated Neutrophil Function In Vivo: Mac-1  Deficiency Abrogates Sustained Fcγ Receptor–dependent  Neutrophil Adhesion and Complement-dependent  Proteinuria in Acute Glomerulonephritis },
  author={Tao Tang and Alexander R. Rosenkranz and Karel J. M. Assmann and Michael J. Goodman and Jos{\'e}-Carlos Gutierrez-Ramos and Michael C Carroll and Ramzi S. Cotran and Tanya Norton Mayadas},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={1853 - 1863}
}
Mac-1 (alphambeta2), a leukocyte adhesion receptor, has been shown in vitro to functionally interact with Fcgamma receptors to facilitate immune complex (IC)-stimulated polymorphonuclear neutrophil (PMN) functions. To investigate the relevance of Mac-1-FcgammaR interactions in IC-mediated injury in vivo, we induced a model of Fc-dependent anti-glomerular basement membrane (GBM) nephritis in wild-type and Mac-1-deficient mice by the intravenous injection of anti-GBM antibody. The initial… CONTINUE READING
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CR3(amb2; CD11b/ CD18) restores IgG-dependent phagocytosis in transfectants expressing a phagocytosis-defective FcgRIIA (CD32) tailminus mutant

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