A Role for MHC Class II Antigen Processing in B Cell Development

  title={A Role for MHC Class II Antigen Processing in B Cell Development},
  author={Tim W. Sproul and Paul C. Cheng and Michelle L. Dykstra and Susan K. Pierce},
  journal={International Reviews of Immunology},
  pages={139 - 155}
For mature B cells, the encounter with foreign antigen results in the selective expansion of the cells and their differentiation into antibody secreting cells or memory B cells. The response of mature B cells to antigen requires not only antigen binding to and signaling through the B cell antigen receptor (BCR) but also the processing and presentation of the BCR bound antigen to helper T cells. Thus, in mature B cells, the ability to process and present antigen to helper T cells plays a… 
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T cell-dependent B cell activation.
  • D. Parker
  • Biology, Medicine
    Annual review of immunology
  • 1993
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