A Role for MHC Class II Antigen Processing in B Cell Development

@article{Sproul2000ARF,
  title={A Role for MHC Class II Antigen Processing in B Cell Development},
  author={T. Sproul and Paul C. Cheng and M. Dykstra and S. Pierce},
  journal={International Reviews of Immunology},
  year={2000},
  volume={19},
  pages={139 - 155}
}
  • T. Sproul, Paul C. Cheng, +1 author S. Pierce
  • Published 2000
  • Biology, Medicine
  • International Reviews of Immunology
For mature B cells, the encounter with foreign antigen results in the selective expansion of the cells and their differentiation into antibody secreting cells or memory B cells. The response of mature B cells to antigen requires not only antigen binding to and signaling through the B cell antigen receptor (BCR) but also the processing and presentation of the BCR bound antigen to helper T cells. Thus, in mature B cells, the ability to process and present antigen to helper T cells plays a… Expand
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