A Role for Innexin2 and Innexin3 Proteins from Spodoptera litura in Apoptosis
@article{Liu2013ARF, title={A Role for Innexin2 and Innexin3 Proteins from Spodoptera litura in Apoptosis}, author={Tian Cheng Liu and Ming Li and Yan Zhang and Zunyu Pang and Wei Xiao and Yang Yang and Kaijun Luo}, journal={PLoS ONE}, year={2013}, volume={8} }
Gap junctions formed by two hemichannels from two neighboring cells are cell-to-cell communication channels; hemichannels are communication channels between intracellular and extracellular environments. Hemichannels are hexameric proteins formed by connexins, pannexins, innexins and vinnexins. Innexin-hemichannels (innexons) exist in the lepidopteran cell surface, but their component innexins and functions have not been reported. Recent studies by others have demonstrated that hemichannels…
26 Citations
TWO INNEXINS OF Spodoptera litura INFLUENCES HEMICHANNEL AND GAP JUNCTION FUNCTIONS IN CELLULAR IMMUNE RESPONSES.
- BiologyArchives of insect biochemistry and physiology
- 2015
A steady-state level of Inxs (SpliInxs) was reported in hemocytes of Spodoptera litura, which formed nonfunctional hemichannels on the cell surface to maintain normal metabolism and provides fundamental knowledge for further study of how steady- state levels of SpliInx are dynamically adjusted to perform cellular immune responses under immune challenge.
A novel innexin2 forming membrane hemichannel exhibits immune responses and cell apoptosis in Scylla paramamosain.
- BiologyFish & shellfish immunology
- 2015
Unexpected link between insect innexins and apoptosis of HeLa cells.
- BiologyArchives of insect biochemistry and physiology
- 2018
This study demonstrates that invertebrate gap junction mRNAs can function in vertebrate cancer cells as tumor suppressors and suggests that mRNA expression of the two Cte-Inxs may activate a Bid-dependent apoptotic pathway in HeLa cells.
Intracellular dynamics of polydnavirus innexin homologues
- BiologyInsect molecular biology
- 2020
The findings support that the Vinnexins may disrupt host cell physiology in a protein‐specific manner through altering gap junctional intercellular channel communication, as well as indirectly by affecting multicellular junction characteristics.
N-TERMINALLY ELONGATED SpliInx2 AND SpliInx3 REDUCE BACULOVIRUS-TRIGGERED APOPTOSIS VIA HEMICHANNEL CLOSURE.
- BiologyArchives of insect biochemistry and physiology
- 2016
An unconventional function of N-terminal-elongated innexins that could act as a plug to manipulate hemichannel closure is identified and provided a mechanism connecting the effect of hemichannels closure directly to apoptotic signaling transduction from intracellular to extracellular compartment.
Virus Innexins induce alterations in insect cell and tissue function.
- BiologyJournal of insect physiology
- 2017
Innexins: Expression, Regulation, and Functions
- BiologyFront. Physiol.
- 2018
This review describes emerging data of possible new roles of innexins and summarizes the data available to date.
Molecular and morphological approach to study the innexin gap junctions in Rhynchosciara americana
- BiologyOpen Biology
- 2021
The molecular characterization results confirm that the message is from a gap junction protein and analysis of the expression and cellular localization profile shows that innexin-2 can participate in many physiological processes during the development of R. americana.
Bracovirus Sneaks Into Apoptotic Bodies Transmitting Immunosuppressive Signaling Driven by Integration-Mediated eIF5A Hypusination
- BiologyFrontiers in Immunology
- 2022
It is shown that ABs transmitted immunosuppressive signaling, causing recipient cells to undergo apoptosis and dismigration, and suggest that integration-mediated eIF5A hypusination drives extracellular vesicles for continuous immunOSuppression.
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