A Role for Innexin2 and Innexin3 Proteins from Spodoptera litura in Apoptosis

@article{Liu2013ARF,
  title={A Role for Innexin2 and Innexin3 Proteins from Spodoptera litura in Apoptosis},
  author={Tian Cheng Liu and Ming Li and Yan Zhang and Zunyu Pang and Wei Xiao and Yang Yang and Kaijun Luo},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
Gap junctions formed by two hemichannels from two neighboring cells are cell-to-cell communication channels; hemichannels are communication channels between intracellular and extracellular environments. Hemichannels are hexameric proteins formed by connexins, pannexins, innexins and vinnexins. Innexin-hemichannels (innexons) exist in the lepidopteran cell surface, but their component innexins and functions have not been reported. Recent studies by others have demonstrated that hemichannels… 
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TWO INNEXINS OF Spodoptera litura INFLUENCES HEMICHANNEL AND GAP JUNCTION FUNCTIONS IN CELLULAR IMMUNE RESPONSES.
TLDR
A steady-state level of Inxs (SpliInxs) was reported in hemocytes of Spodoptera litura, which formed nonfunctional hemichannels on the cell surface to maintain normal metabolism and provides fundamental knowledge for further study of how steady- state levels of SpliInx are dynamically adjusted to perform cellular immune responses under immune challenge.
A novel innexin2 forming membrane hemichannel exhibits immune responses and cell apoptosis in Scylla paramamosain.
Unexpected link between insect innexins and apoptosis of HeLa cells.
TLDR
This study demonstrates that invertebrate gap junction mRNAs can function in vertebrate cancer cells as tumor suppressors and suggests that mRNA expression of the two Cte-Inxs may activate a Bid-dependent apoptotic pathway in HeLa cells.
Bracovirus-mediated innexin hemichannel closure in cell disassembly
Intracellular dynamics of polydnavirus innexin homologues
TLDR
The findings support that the Vinnexins may disrupt host cell physiology in a protein‐specific manner through altering gap junctional intercellular channel communication, as well as indirectly by affecting multicellular junction characteristics.
N-TERMINALLY ELONGATED SpliInx2 AND SpliInx3 REDUCE BACULOVIRUS-TRIGGERED APOPTOSIS VIA HEMICHANNEL CLOSURE.
TLDR
An unconventional function of N-terminal-elongated innexins that could act as a plug to manipulate hemichannel closure is identified and provided a mechanism connecting the effect of hemichannels closure directly to apoptotic signaling transduction from intracellular to extracellular compartment.
Virus Innexins induce alterations in insect cell and tissue function.
Innexins: Expression, Regulation, and Functions
TLDR
This review describes emerging data of possible new roles of innexins and summarizes the data available to date.
Molecular and morphological approach to study the innexin gap junctions in Rhynchosciara americana
TLDR
The molecular characterization results confirm that the message is from a gap junction protein and analysis of the expression and cellular localization profile shows that innexin-2 can participate in many physiological processes during the development of R. americana.
Bracovirus Sneaks Into Apoptotic Bodies Transmitting Immunosuppressive Signaling Driven by Integration-Mediated eIF5A Hypusination
TLDR
It is shown that ABs transmitted immunosuppressive signaling, causing recipient cells to undergo apoptosis and dismigration, and suggest that integration-mediated eIF5A hypusination drives extracellular vesicles for continuous immunOSuppression.
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References

SHOWING 1-10 OF 55 REFERENCES
Characterization of Nonjunctional Hemichannels in Caterpillar Cells
TLDR
These results demonstrate for the first time the activity of nonjunctional hemichannels in insect cells, as well as pharmacological tools to manipulate them, which will facilitate the further examination of the role of innexins and nonj Junctionine hemich channels in insect cell biology, including paracrine signaling, and comparative studies of mammalian pannexin homologues termed innexin.
Functional Interactions between Polydnavirus and Host Cellular Innexins
TLDR
Data suggest that altered gap junctional intercellular communication may underlie certain cellular pathologies associated with ichnovirus infection of caterpillar hosts.
Innexins: members of an evolutionarily conserved family of gap-junction proteins.
  • P. Phelan
  • Biology
    Biochimica et biophysica acta
  • 2005
Functional gap junction genes are encoded by insect viruses
Paracrine signaling through plasma membrane hemichannels.
Pathogenic Connexin-31 Forms Constitutively Active Hemichannels to Promote Necrotic Cell Death
TLDR
It is reported here that expression of EKV pathogenic mutant Cx31R42P induces cell death with necrotic characteristics and constitutively active hemichannels are likely resulted by an ER stress mediated ROS overproduction.
Gap junctional proteins of animals: the innexin/pannexin superfamily.
  • M. Yen, M. Saier
  • Biology
    Progress in biophysics and molecular biology
  • 2007
Replication of Spodoptera exigua nucleopolyhedrovirus in permissive and non-permissive lepidopteran cell lines.
TLDR
Findings indicate that the SeMNPV replication was restricted at various points in dependence upon each cell line, as well as indicating that the infected CLS-79 cells underwent apoptosis.
Connexins, pannexins, innexins: novel roles of “hemi-channels”
TLDR
There is no longer any question that vertebrate gap junction channels are made by various combinations of different connexin proteins, and these differences have functional consequences, as most elegantly demonstrated by co-culturing cell lines from different animal species.
An Integrin-Tetraspanin Interaction Required for Cellular Innate Immune Responses of an Insect, Manduca sexta*
TLDR
These studies involving antibody blocking, RNA interference, and binding assays imply a trans interaction of integrin and tetraspanin on hemocyte surfaces.
...
...