A Role for Groucho Tetramerization in Transcriptional Repression

@article{Chen1998ARF,
  title={A Role for Groucho Tetramerization in Transcriptional Repression},
  author={G. Chen and P. Nguyen and A. Courey},
  journal={Molecular and Cellular Biology},
  year={1998},
  volume={18},
  pages={7259 - 7268}
}
ABSTRACT The Drosophila Groucho (Gro) protein is a corepressor required by a number of DNA-binding transcriptional repressors. Comparison of Gro with its homologues in other eukaryotic organisms reveals that Gro contains, in addition to a conserved C-terminal WD repeat domain, a conserved N-terminal domain, which has previously been implicated in transcriptional repression. We determined, via a variety of hydrodynamic measurements as well as protein cross-linking, that native Gro is a tetramer… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Groucho-dependent and -independent repression activities of Runt domain proteins.
Products of the grg (Groucho-related Gene) Family Can Dimerize through the Amino-terminal Q Domain*
Groucho: making its Marx as a transcriptional co-repressor.
The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs.
...
1
2
3
4
5
...