A Role for Dopamine in the Centrally Mediated Sympathetic Response in Rats with Type 2 Diabetes Induced by Streptozotocin and a High-fat Diet

@inproceedings{Zheng2011ARF,
  title={A Role for Dopamine in the Centrally Mediated Sympathetic Response in Rats with Type 2 Diabetes Induced by Streptozotocin and a High-fat Diet},
  author={Hong Chun Zheng and Xuefei Liu and Kaushik K Patel},
  year={2011}
}
Dopamine plays an important role in the central nervous system to regulate sympathetic activity and cardiovascular function. The present study was conducted to investigate the role for dopamine in the centrally mediated sympathetic response in rats with type 2 diabetes. To generate a rat model mimicking human type 2 diabetes with increased adiposity, we used a combination of high-fat diet (HFD, 42% of calories of fat, 3 months) and low-dose streptozotocin (STZ, 30mg/kg, i.p). In anaesthetized… CONTINUE READING

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