A Role for Cdc2- and PP2A-Mediated Regulation of Emi2 in the Maintenance of CSF Arrest

@article{Wu2007ARF,
  title={A Role for Cdc2- and PP2A-Mediated Regulation of Emi2 in the Maintenance of CSF Arrest},
  author={Qiju Wu and Yanxiang Guo and Ayumi Yamada and Jennifer A. Perry and Michael Zhuo Wang and Marito Araki and Christopher D. Freel and Jeffrey J. Tung and Wanli Lily Tang and Seth S. Margolis and Peter Kent Jackson and Hiroyuki Yamano and Maki Asano and Sally Kornbluth},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={213-224}
}
BACKGROUND Vertebrate oocytes are arrested in metaphase II of meiosis prior to fertilization by cytostatic factor (CSF). CSF enforces a cell-cycle arrest by inhibiting the anaphase-promoting complex (APC), an E3 ubiquitin ligase that targets Cyclin B for degradation. Although Cyclin B synthesis is ongoing during CSF arrest, constant Cyclin B levels are maintained. To achieve this, oocytes allow continuous slow Cyclin B degradation, without eliminating the bulk of Cyclin B, which would induce… CONTINUE READING
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