A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling

@article{Wei1999ARF,
  title={A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling },
  author={Ying Wei and Xiuwei Yang and Qiumei Liu and John A. Wilkins and Harold A Chapman},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={144},
  pages={1285 - 1294}
}
The assembly of signaling molecules surrounding the integrin family of adhesion receptors remains poorly understood. Recently, the membrane protein caveolin was found in complexes with beta1 integrins. Caveolin binds cholesterol and several signaling molecules potentially linked to integrin function, e.g., Src family kinases, although caveolin has not been directly implicated in integrin-dependent adhesion. Here we report that depletion of caveolin by antisense methodology in kidney 293 cells… CONTINUE READING