A Role for CD4 in Peripheral T Cell Differentiation

  title={A Role for CD4 in Peripheral T Cell Differentiation},
  author={Daniel R. Brown and Naomi H. Moskowitz and Nigel Killeen and Steven L Reiner},
  journal={The Journal of Experimental Medicine},
  pages={101 - 107}
Naive CD4+ T helper cells (Th) differentiate into one of two well-defined cell types during immune responses. Mature Th1 and Th2 cells regulate the type of response as a consequence of the unique cytokines that they secrete. CD4 serves a prominent role in potentiating antigen recognition by helper T cells. We have examined the role of CD4 in peripheral T cell differentiation by studying helper T cells from mice with a congenital defect in CD4 expression. After protein immunization or infection… CONTINUE READING


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