A Robust Network of Double-Strand Break Repair Pathways Governs Genome Integrity during C. elegans Development

@article{Pontier2009ARN,
  title={A Robust Network of Double-Strand Break Repair Pathways Governs Genome Integrity during C. elegans Development},
  author={Daphne B. Pontier and Marcel Tijsterman},
  journal={Current Biology},
  year={2009},
  volume={19},
  pages={1384-1388}
}
To preserve genomic integrity, various mechanisms have evolved to repair DNA double-strand breaks (DSBs). Depending on cell type or cell cycle phase, DSBs can be repaired error-free, by homologous recombination, or with concomitant loss of sequence information, via nonhomologous end-joining (NHEJ) or single-strand annealing (SSA). Here, we created a transgenic reporter system in C. elegans to investigate the relative contribution of these pathways in somatic cells during animal development… CONTINUE READING

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