A Robust, Recyclable Resin for Decagram Scale Resolution of (±)-Mefloquine and Other Chiral N-Heterocycles.

@article{Kreituss2016ARR,
  title={A Robust, Recyclable Resin for Decagram Scale Resolution of (±)-Mefloquine and Other Chiral N-Heterocycles.},
  author={Imants Kreituss and Kuang-Yen Chen and Simon H Eitel and Jean-Michel Adam and Georg Wuitschik and Alec Fettes and Jeffrey W Bode},
  journal={Angewandte Chemie},
  year={2016},
  volume={55 4},
  pages={1553-6}
}
Decagram quantities of enantiopure (+)-mefloquine have been produced via kinetic resolution of racemic mefloquine using a ROMP-gel supported chiral acyl hydroxamic acid resolving agent. The requisite monomer was prepared in a few synthetic steps without chromatography and polymerization was safely performed on a >30 gram scale under ambient conditions. The reagent was readily regenerated and reused multiple times for the resolution of 150 grams of (±)-mefloquine and other chiral N-heterocylces.