A Road Map for Those Who Don't Know JAK-STAT

  title={A Road Map for Those Who Don't Know JAK-STAT},
  author={David Seth Aaronson and Curt M. Horvath},
  pages={1653 - 1655}
The Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to target gene promoters in the nucleus, providing a mechanism for transcriptional regulation without second messengers. Evolutionarily conserved in eukaryotic organisms from slime molds to humans, JAK-STAT signaling appears to be an early adaptation to facilitate intercellular communication that has… 

STAT signaling in the intestine.

Natural products and their derivatives regulating the janus kinase/signal transducer and activator of transcription pathway

This review attempts to summarize the current status of natural products and their derivatives regulating the proteins or transcription elements of JAK/STAT signaling pathway to supply a new direction or drug targets for the discovery of new drugs.

The JAK / STAT Signaling Pathway

The Janus kinase/signal transducers and activators of transcription (JAK/STAT)pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and

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The JAK/STAT Pathway Is Involved in Synaptic Plasticity

Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes

Canonical and non-canonical JAK/STAT genes may regulate distinct and overlapping sets of genes and may perform specific overall functions in physiology.



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The roles of STAT-interacting proteins in the regulation of STAT signaling are reviewed, finding a number of proteins function to modulate STAT signaling at various steps and mediate the crosstalk of STATs with other cellular signaling pathways.

Role of Jak Kinases and STATs in Cytokine Signal Transduction

  • W. Leonard
  • Biology
    International journal of hematology
  • 2001
This review summarizes salient features of the Jak-STAT pathway and focuses on the functional role of the different Jak kinases and STATs in vivo.

SOCS Proteins: Negative Regulators of Cytokine Signaling

Gene targeting has been used to generate mice lacking socs1, socs2, or socs3, in order to elucidate the physiological function of these SOCS family members, and it is revealed that SOCS1 plays a key role in the negative regulation of interferon‐γ signaling and in T cell differentiation.

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

Since the IL-6/gp130/STAT3 signaling pathway is involved in both B cell growth and differentiation into plasma cells it is likely to play a central role in the generation of plasma cell neoplasias.

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Recently studies show the activation and involvement of Src and Stat3 pathways in Gαo and Gαi mediated transformation of cells and suggest that both G αi and G αs may be able to interact with and activate Src.

A nuclear tyrosine phosphatase downregulates interferon-induced gene expression

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Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes.

It is shown that the BRCA1 tumor suppressor acts in concert with STAT1 to differentially activate transcription of a subset of IFN-gamma target genes and mediates growth inhibition by this cytokine.

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This review addresses recent advances in understanding the regulation of STAT serine phosphorylation, as well as the kinases and other signal transducers implied in this process.

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Selective STAT Protein Degradation Induced by Paramyxoviruses Requires both STAT1 and STAT2 but Is Independent of Alpha/Beta Interferon Signal Transduction

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