A Road Map for Those Who Don't Know JAK-STAT

@article{Aaronson2002ARM,
  title={A Road Map for Those Who Don't Know JAK-STAT},
  author={David Seth Aaronson and Curt M. Horvath},
  journal={Science},
  year={2002},
  volume={296},
  pages={1653 - 1655}
}
The Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to target gene promoters in the nucleus, providing a mechanism for transcriptional regulation without second messengers. Evolutionarily conserved in eukaryotic organisms from slime molds to humans, JAK-STAT signaling appears to be an early adaptation to facilitate intercellular communication that has… 

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