A Rise in Ionized Calcium Activates the Neutrophil NADPH-Oxidase But Is Not Sufficient to Directly Translocate Cytosolic p47phox or p67phox to b Cytochrome Containing Membranes

@article{Movitz1997ARI,
  title={A Rise in Ionized Calcium Activates the Neutrophil NADPH-Oxidase But Is Not Sufficient to Directly Translocate Cytosolic p47phox or p67phox to b Cytochrome Containing Membranes},
  author={Charlotta Movitz and Carola Sj{\"o}lin and Claes Dahlgren},
  journal={Inflammation},
  year={1997},
  volume={21},
  pages={531-540}
}
Neutrophil production of reactive oxygen species is dependent on an assembly process that involves a translocation of the cytosolic NADPH-oxidase components (p47phox; p67phox; Rac2) to a b cytochrome containing membrane. Based on the fact that an intracellular Ca2+ rise can activate the oxidase without any extracellular release of reactive oxygen species, we suggest that the oxidase can be assembled in a membrane distinct from the plasma membrane. Disintegrated cells were used to monitor Ca2… CONTINUE READING