A-Ring Synthons of 19-Nor Type Vitamin D Derivatives.

@article{Akagi2017ARingSO,
  title={A-Ring Synthons of 19-Nor Type Vitamin D Derivatives.},
  author={Yusuke Akagi and Koji Yasui and Kazuo Nagasawa},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2017},
  volume={173},
  pages={64-68}
}
Various 19-nor vitamin D analogs, which lack the methylene group at C19, exhibit significant vitamin D (VD)-related biological activities, but generally show a reduced calcemic side-effect compared with VD itself. Among them, paricalcitol is already used clinically for treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure. Therefore, considerable synthetic efforts have been directed towards 19-nor VD analogs, focusing especially on A-ring synthons… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
AlkenesNo subtypediene
For example , we have recently developed a new synthetic route to A - ring synthons from linear dienes based upon a ring - closing olefin metathesis strategy .
dieneNo subtypeAlkenes
For example , we have recently developed a new synthetic route to A - ring synthons from linear dienes based upon a ring - closing olefin metathesis strategy .
Among them , paricalcitol is already used clinically for treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure .
All Topics