• Corpus ID: 163163220

A Review on Micronization Techniques

  title={A Review on Micronization Techniques},
  author={Jalay T. Joshi},
Drug powders containing micron-size drug particles are used in several pharmaceutical dosage forms. Many drugs, especially newly developed substances, are poorly water soluble, which limits their oral bioavailability. The dissolution rate can be enhanced by using micronized drugs. Small drug particles are also required in administration forms, which require the drug in micron-size size due to geometric reasons in the organ to be targeted (e.g., drugs for pulmonary use). The common technique for… 

Figures from this paper

An overview on in situ micronization technique - An emerging novel concept in advanced drug delivery.

Production of functional pharmaceutical nano/micro-particles by solvent displacement method using advanced micro-engineered dispersion devices

The rapid advancement of drug delivery systems (DDS) has raised the possibility of using functional engineered nano/micro-particles as drug carriers for the administration of active pharmaceutical

Dry Powder for Pulmonary Delivery: A Comprehensive Review

The aim of this review is to provide an overview of the respiratory tract structure, particle deposition patterns, and possible drug-clearance mechanisms from the lungs, including the physicochemical properties of dry powder, various techniques used for the preparation of dry powders, and factors affecting the clinical efficacy, as well as various challenges that need to be addressed in the future.

Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems

The self-emulsifying system offers various advantages over other drug delivery systems having potential to solve various problems associated with drugs of all the classes of biopharmaceutical classification system (BCS).

Naproxen Microparticulate Systems Prepared Using In Situ Crystallisation and Freeze-Drying Techniques

The aim of this research was to investigate the effects of the surfactants, poloxamer 407 (P407) and caprol® PGE 860 (CAP), at various concentrations on the enhancement of the dissolution properties of poorly water-soluble drug, naproxen, using in situ micronisation by solvent change method and freeze-drying.

Micronized Zaleplon Delivery via Orodispersible Film and Orodispersible Tablets

The orodispersible formulations containing micronized zaleplon have a strong potential for rapid disintegration following superior absorption in solution state through oral cavity into the blood stream, envisaging better oral delivery.

Enhancing the solubility of nitazoxanide with solid dispersions technique: formulation, evaluation, and cytotoxicity study

In vitro dissolution of the poorly soluble drug NTZ through amorphous solid dispersion technology was improved and the newly developed formulation was found to be safe and stable with enhanced solubility profile.

Characterization of nimesulide and development of immediate release tablets

To characterize nimesulide raw materials from different manufacturers and to develop immediate release tablets, in order to register a generic product. Also raw material characteristics and the


The present chapter briefly describes the critical properties of gentamicin from both a pharmacological and technological point of view and illustrates “particle engineering” strategies, i.e. spray drying and supercritical fluid techniques, adopted to improve technological properties of GS raw material.



Engineering Powder Properties By Supercritical Fluid for Optimum Drug Delivery

  • Chemistry
  • 2005
B ioavailability of pharmaceutical active ingredients can be influenced by particle size distribution and morphology. Production of micronic and submicronic drug particles within a narrow size

Supercritical fluids-assisted micronization techniques. Low-impact routes for particle production

Abstract Micronized powders are of interest in many industrial fields; pharmaceuticals, catalysts, pigments, and biopolymers, for example, are some categories of products that can be used as

Micronization of drugs using supercritical carbon dioxide.

Supercritical assisted atomization: A novel technology for microparticles preparation of an asthma-controlling drug

A good control of particle size and distribution together with no drug degradation was obtained by SAA process, proposed as an alternative to conventional jet-milling process.

Preparation of drug delivery systems using supercritical fluid technology.

This review summarizes some of the recent applications of supercritical fluid technology in the preparation of drug delivery systems, with polymer separation enabling the selection of a pure fraction of a polymer, thereby allowing a more precise control of drug release from polymeric delivery systems.

Influence of process parameters in the ASES process on particle properties of budesonide for pulmonary delivery.

  • H. SteckelLars PichertB. Müller
  • Materials Science
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2004

Preparation of Active Proteins, Vaccines and Pharmaceuticals as Fine Powders using Supercritical or Near-Critical Fluids

A recently developed process known as CO2-assisted nebulization with a Bubble Dryer® (CAN-BD) has been demonstrated to have broad applicability to small-molecule as well as macromolecule substances (including therapeutic proteins).

Low-temperature manufacturing of fine pharmaceutical powders with supercritical fluid aerosolization in a Bubble Dryer®

Abstract Aerosols play an important role in thin film deposition, fine powder generation, and drug delivery. Green processes to form aerosols are needed to eliminate the use of toxic organic solvents