A Review of the Use of Infliximab to Manage Cutaneous Dermatoses

@article{Gupta2004ARO,
  title={A Review of the Use of Infliximab to Manage Cutaneous Dermatoses},
  author={Aditya K. Gupta and Alayne R. Skinner},
  journal={Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology},
  year={2004},
  volume={8},
  pages={77-89}
}
BackgroundInfliximab is a chimeric monoclonal antibody that binds specifically to human tumor necrosis factor-alpha (TNF-α), decreasing the effect of the cytokine in inflammatory diseases.ObjectiveThe aim of this study was to review the efficacy and safety of infliximab in the treatment of dermatological diseases.MethodsA MEDLINE search (1966–January 2003), using the keyword “infliximab” was performed to find relevant articles pertaining to the use of infliximab in dermatology.ResultsInfliximab… 
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57 Citations
Background Citations
10
Methods Citations
1
Results Citations
1

Tables from this paper

57 Citations

Lymphoedematous variants of Kaposi's sarcoma
  • L. Pantanowitz, W. Duke
  • Medicine, Biology
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2008
TLDR
The beneficial effects of infliximab may support the hypothesis of a possible role of TNFα in the pathophysiolgical mechanism of PRP.
Infliximab in dermatological treatment: beyond psoriasis
TLDR
The possible future uses of infliximab in dermatology are being reviewed, and its TNF-α binding capacity is being reviewed.
Infliximab-induced discoid lupus erythematosus
TLDR
A case of rheumatoid arthritis which developed a discoid lupus erythematosus-like eruption linked to its use after treatment with infliximab is presented.
Beneficial and rapid effect of infliximab on the course of toxic epidermal necrolysis.
TLDR
Infliximab is a chimeric monoclonal antibody with human and mouse components that binds specifically to both soluble and membrane-bound TNF-α, which implies that a selective T NF-α blockade could be a new and promising type of treatment.
The use of infliximab in dermatology
  • S. Rott, U. Mrowietz
  • Medicine, Biology
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2007
TLDR
Autoimmune diseases like Crohn's disease, rheumatoid arthritis (RA) and psoriasis are often difficult to treat due to complex underlying immunologic pathways, and especially infliximab became widely used.
Infliximab and Golimumab
TLDR
This chapter provides a comprehensive review of the safety and efficacy of two of the monoclonal antibody tumor necrosis factor alpha (TNFα) blocking drugs.
Is there a role for infliximab in the current therapy of hidradenitis suppurativa? A report of three treated cases
  • S. Moschella
  • Medicine
    International journal of dermatology
  • 2007
TLDR
Hidradenitis suppurativa is one of the follicular occlusion diseases favoring the flexural areas of the body and there is a need for effective medical anti‐inflammatory therapy to control the disease and minimize the pathologic and socioeconomic consequences of the disease process.
[Hidradenitis suppurativa. Response to treatment with infliximab].
Type III juvenile pityriasis rubra pilaris: a successful treatment with infliximab
TLDR
This is the first case of classic juvenile-onset PRP (type III) dramatically improved following anti-tumour necrosis factor-α (TNFα) therapy and a significant reduction of the erythema, itch, and desquamation was observed at the second infusion.
[Efficacy of etanercept in the treatment of acne conglobata].
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