A Review of the Pharmacokinetics of Abacavir

@article{Yuen2008ARO,
  title={A Review of the Pharmacokinetics of Abacavir},
  author={Geoffrey J. Yuen and Stephen Weller and Gary E. Pakes},
  journal={Clinical Pharmacokinetics},
  year={2008},
  volume={47},
  pages={351-371}
}
Abacavir is a carbocyclic 2′-deoxyguanosine nucleoside reverse transcriptase inhibitor that is used as either a 600-mg once-daily or 300-mg twice-daily regimen exclusively in the treatment of HIV infection. Abacavir is rapidly absorbed after oral administration, with peak concentrations occurring 0.63–1 hour after dosing. The absolute bioavailability of abacavir is approximately 83%. Abacavir pharmacokinetics are linear and doseproportional over the range of 300–1200 mg/day. To date, one study… 

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Population pharmacokinetics and maximum a posteriori probability Bayesian estimator of abacavir: application of individualized therapy in HIV-infected infants and toddlers.

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TLDR
In patients with HIV-1-infected patients with various degrees of renal dysfunction, absorption, elimination and distribution phases were not altered by renal insufficiency, and pharmacokinetic data are similar to those obtained in patients with normal renal function.

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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