A Review of Vitamin B12 in Dermatology

  title={A Review of Vitamin B12 in Dermatology},
  author={Jennifer Brescoll and Steven Daveluy},
  journal={American Journal of Clinical Dermatology},
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry and metabolism of cobalamin is complex, and diseases can be associated with alterations of this metabolic pathway. The cutaneous manifestations of cobalamin deficiency include… 

Recognition and management of vitamin B12 deficiency: Report of four cases with oral manifestations.

Oral supplementation for vitamin B12 deficiency was conducted/realized in three patients, while one patient was treated with parenteral doses and showed partial or total remission of the signs and symptoms.

A case report on hyperpigmentation in vitamin B12 deficiency

A 36-year-old female presented with generalised weakness and progressive and asymptomatic hyperpigmentation of hand and feet for 5 months and the possibility of vitamin B12 or folate deficiency in a patient with unexplained pigmentary changes is considered.

Cobalamin Deficiency in the Elderly

The essential role of cobalamin in humans, the possible causes and impact of deficiency, the diagnostic challenges and the therapeutic options, between old and emerging concepts, are traced, with a particular focus on the elderly.

Hypervitaminosis B12

The aim of the study was to determine the effect of increased concentrations of vitamin B12 onto human health, which is most commonly caused by a disease, while disorders due to inadequate intake and overdose are much less common.

Skin lesions in a patient with Cobalamin C disease in poor metabolic control

It appears that skin lesion in cobalamin C disease is directly related to underlying metabolic defect and not nutritional deficiencies and therefore should be considered for consideration of poor metabolic control due to noncompliance or inadequate doses.


The importance of knuckle hyperpigmentation as an early cutaneous sign of vitamin B12 deficiency which points an important clue towards the aetiology of Megaloblastic anemia is highlighted.

Role of vitamin B12 in treating recurrent aphthous stomatitis: A review.

It is suggested that a daily dose of 1000 μg of vitamin B12 sublingually for six months can be used to treat RAS, although this conclusion should be considered tentative due to the lack of high quality, large scale studies.


The aim of the study was to determine the effect of increased concentrations of vitamin B12 onto human health, which is most commonly caused by a disease, while disorders due to inadequate intake and overdose are much less common.



Vitamin B12 deficiency

The current knowledge surrounding B 12 deficiency is described, and improvements in diagnostic methods as well as shifting concepts about the prevalence, causes and manifestations of B12 deficiency are highlighted.

Significance of elevated cobalamin (vitamin B12) levels in blood.

The pathophysiology of elevated vitamin B12 in clinical practice.

The aetiological profile of high serum cobalamin predominantly encompasses severe disease entities for which early diagnosis is critical for prognosis, and the potential importance of the vitamin B12 assay as an early diagnostic marker of these diseases is reflected.

Generalized Hyperpigmentation of the Skin due to Vitamin B12 Deficiency

It is considered that the dominant mechanism of hyperpigmentation due to vitamin B12 deficiency is not a defect in melanin transport but is rather an increase inmelanin synthesis.

Progressive hyperpigmentation in a Taiwanese child due to an inborn error of vitamin B12 metabolism (cblJ)

This case demonstrates that defects or deficiencies of cobalamin should be remembered in the differential diagnosis of diffuse hyperpigmentary skin disorders, and using whole‐exome sequencing identified a homozygous mutation in ABCD4 (c.423C>G; p.Asn141Lys), which encodes an ATP‐binding cassette transporter with a role in the intracellular processing ofcobalamin.

Vitamin B12 absorption: mammalian physiology and acquired and inherited disorders.

Reintroduction of vitamin B12 in 2 patients with prior B12‐induced anaphylaxis

2 patients with past medical histories of severe hypersensitivity to one of the cobalamin forms in which could be given the other form, in tandem with anti-allergy prophylaxis, in whom no allergic reaction ensued are reported on.

Recreational Nitrous Oxide Abuse-Induced Vitamin B12 Deficiency in a Patient Presenting with Hyperpigmentation of the Skin

It is recommended that dermatologists consider N2O intoxication-induced vitamin B12 deficiency as a potential cause of skin hyperpigmentation and myeloneuropathy of the posterior and lateral columns in young, otherwise healthy patients.

Glossitis with linear lesions: an early sign of vitamin B12 deficiency.

Cobalamin pseudodeficiency due to a transcobalamin I deficiency.

A case in which a patient has an R-binder deficiency, specifically transcobalamin I deficiency, with a low vitamin B12 level but no true vitamin B 12 deficiency is reported.