A Review of Vitamin B12 in Dermatology

@article{Brescoll2015ARO,
  title={A Review of Vitamin B12 in Dermatology},
  author={Jennifer Brescoll and Steven Daveluy},
  journal={American Journal of Clinical Dermatology},
  year={2015},
  volume={16},
  pages={27-33}
}
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry and metabolism of cobalamin is complex, and diseases can be associated with alterations of this metabolic pathway. The cutaneous manifestations of cobalamin deficiency include… 
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References

SHOWING 1-10 OF 52 REFERENCES
Vitamin B12 allergy and successful desensitisation with cyanocobalamin: a case report.
Vitamin B12 deficiency
TLDR
The current knowledge surrounding B 12 deficiency is described, and improvements in diagnostic methods as well as shifting concepts about the prevalence, causes and manifestations of B12 deficiency are highlighted.
Significance of elevated cobalamin (vitamin B12) levels in blood.
The pathophysiology of elevated vitamin B12 in clinical practice.
TLDR
The aetiological profile of high serum cobalamin predominantly encompasses severe disease entities for which early diagnosis is critical for prognosis, and the potential importance of the vitamin B12 assay as an early diagnostic marker of these diseases is reflected.
Generalized Hyperpigmentation of the Skin due to Vitamin B12 Deficiency
TLDR
It is considered that the dominant mechanism of hyperpigmentation due to vitamin B12 deficiency is not a defect in melanin transport but is rather an increase inmelanin synthesis.
Progressive hyperpigmentation in a Taiwanese child due to an inborn error of vitamin B12 metabolism (cblJ)
TLDR
This case demonstrates that defects or deficiencies of cobalamin should be remembered in the differential diagnosis of diffuse hyperpigmentary skin disorders, and using whole‐exome sequencing identified a homozygous mutation in ABCD4 (c.423C>G; p.Asn141Lys), which encodes an ATP‐binding cassette transporter with a role in the intracellular processing ofcobalamin.
Vitamin B12 absorption: mammalian physiology and acquired and inherited disorders.
Reintroduction of vitamin B12 in 2 patients with prior B12‐induced anaphylaxis
TLDR
2 patients with past medical histories of severe hypersensitivity to one of the cobalamin forms in which could be given the other form, in tandem with anti-allergy prophylaxis, in whom no allergic reaction ensued are reported on.
Recreational Nitrous Oxide Abuse-Induced Vitamin B12 Deficiency in a Patient Presenting with Hyperpigmentation of the Skin
TLDR
It is recommended that dermatologists consider N2O intoxication-induced vitamin B12 deficiency as a potential cause of skin hyperpigmentation and myeloneuropathy of the posterior and lateral columns in young, otherwise healthy patients.
Glossitis with linear lesions: an early sign of vitamin B12 deficiency.
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