A Review of Vitamin B12 in Dermatology

@article{Brescoll2015ARO,
  title={A Review of Vitamin B12 in Dermatology},
  author={Jennifer Brescoll and Steven Daveluy},
  journal={American Journal of Clinical Dermatology},
  year={2015},
  volume={16},
  pages={27-33}
}
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry and metabolism of cobalamin is complex, and diseases can be associated with alterations of this metabolic pathway. The cutaneous manifestations of cobalamin deficiency include… 
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55 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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55 Citations

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Citation Type

Recognition and management of vitamin B12 deficiency: Report of four cases with oral manifestations.
TLDR
Oral supplementation for vitamin B12 deficiency was conducted/realized in three patients, while one patient was treated with parenteral doses and showed partial or total remission of the signs and symptoms.
A case report on hyperpigmentation in vitamin B12 deficiency
TLDR
A 36-year-old female presented with generalised weakness and progressive and asymptomatic hyperpigmentation of hand and feet for 5 months and the possibility of vitamin B12 or folate deficiency in a patient with unexplained pigmentary changes is considered.
Vitamin deficiencies/hypervitaminosis and the skin
Cobalamin Deficiency in the Elderly
TLDR
The essential role of cobalamin in humans, the possible causes and impact of deficiency, the diagnostic challenges and the therapeutic options, between old and emerging concepts, are traced, with a particular focus on the elderly.
Hypervitaminosis B12
TLDR
The aim of the study was to determine the effect of increased concentrations of vitamin B12 onto human health, which is most commonly caused by a disease, while disorders due to inadequate intake and overdose are much less common.
Skin lesions in a patient with Cobalamin C disease in poor metabolic control
TLDR
It appears that skin lesion in cobalamin C disease is directly related to underlying metabolic defect and not nutritional deficiencies and therefore should be considered for consideration of poor metabolic control due to noncompliance or inadequate doses.
KNUCKLE HYPERPIGMENTATION AS A PRELIMINARY MARKER OF VITAMIN B 12 DEFICIENCY: A CASE SERIES
TLDR
The importance of knuckle hyperpigmentation as an early cutaneous sign of vitamin B12 deficiency which points an important clue towards the aetiology of Megaloblastic anemia is highlighted.
Role of vitamin B12 in treating recurrent aphthous stomatitis: A review.
TLDR
It is suggested that a daily dose of 1000 μg of vitamin B12 sublingually for six months can be used to treat RAS, although this conclusion should be considered tentative due to the lack of high quality, large scale studies.
HYPERVITAMINOSIS B12 HIPERVITAMINOzA B12
TLDR
The aim of the study was to determine the effect of increased concentrations of vitamin B12 onto human health, which is most commonly caused by a disease, while disorders due to inadequate intake and overdose are much less common.
Vitamin B12 Deficiency Presenting with Neurological Dysfunction in an Adolescent.
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References

SHOWING 1-10 OF 52 REFERENCES
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TLDR
The current knowledge surrounding B 12 deficiency is described, and improvements in diagnostic methods as well as shifting concepts about the prevalence, causes and manifestations of B12 deficiency are highlighted.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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