A Review of Traditional and Novel Treatments for Seizures in Autism Spectrum Disorder: Findings from a Systematic Review and Expert Panel

@article{Frye2013ARO,
  title={A Review of Traditional and Novel Treatments for Seizures in Autism Spectrum Disorder: Findings from a Systematic Review and Expert Panel},
  author={R. Frye and D. Rossignol and M. Casanova and G. Brown and Victoria Martin and S. Edelson and R. Coben and J. Lewine and J. Slattery and Chrystal Lau and P. Hardy and S. Fatemi and T. D. Folsom and D. Macfabe and James B Adams},
  journal={Frontiers in Public Health},
  year={2013},
  volume={1}
}
Despite the fact that seizures are commonly associated with autism spectrum disorder (ASD), the effectiveness of treatments for seizures has not been well studied in individuals with ASD. This manuscript reviews both traditional and novel treatments for seizures associated with ASD. Studies were selected by systematically searching major electronic databases and by a panel of experts that treat ASD individuals. Only a few anti-epileptic drugs (AEDs) have undergone carefully controlled trials in… Expand
Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes
TLDR
There is evidence for some children with ASD being affected by seizure and epilepsy, neurotransmitter dysfunction, sleep disorders, metabolic abnormalities, including abnormalities in folate, cobalamin, tetrahydrobiopterin, carnitine, redox and mitochondrial metabolism, and immune and gastrointestinal disorders. Expand
The Use of Medications Approved for Alzheimer’s Disease in Autism Spectrum Disorder: A Systematic Review
TLDR
Both galantamine and memantine had sufficient evidence ranking for improving both core and associated symptoms of ASD, and further studies on novel medications, including Alzheimer’s disease medications, are needed. Expand
Epilepsy in Children with ASD: An Overview of Evaluation Procedures, Child Characteristics and Treatment Options
Abstract The rates of epilepsy among children with autism spectrum disorders (ASD) are higher than that of the general population. The exact prevalence and aetiology of the comorbidity of autism andExpand
Rating of the Effectiveness of 26 Psychiatric and Seizure Medications for Autism Spectrum Disorder: Results of a National Survey
TLDR
An evaluation of the benefits and adverse effects of psychiatric and seizure medications commonly used for individuals with autism spectrum disorder (ASD) shows generally good agreement in terms of medication benefits with some differences; in some cases the differences are because the clinical trials did not assess all of the symptoms assessed by this survey. Expand
Autism with epilepsy: A neurodevelopmental association
Introduction The association between Autism Spectrum Disorders (ASD) and epilepsy has been extensively documented and the estimated prevalence varies, depending upon the selected population and theExpand
Epilepsy Associated with ASD and Intellectual Disability
Abstract The co-occurrence of autism spectrum disorder (ASD), intellectual disability (ID), and epilepsy is well established among clinicians and researchers. Epilepsy is reported to occur in ASD,Expand
Therapies for Children With Autism Spectrum Disorder: Behavioral Interventions Update
Objective We updated a prior systematic review of interventions for children (0–12 years) with autism spectrum disorder (ASD), focusing on recent studies of behavioral interventions. Data sources WeExpand
Effect of a ketogenic diet on autism spectrum disorder: A systematic review
Abstract Autism spectrum disorder (ASD) is primarily characterized by impaired social interaction and communication, as well as restricted repetitive behaviours and interests. The utilization of theExpand
Metabolism-Based Treatments for Autism Spectrum Disorder and Co-Morbidities
Autism spectrum disorder (hereafter referred to as “ASD”) has broad and heterogeneous clinical manifestations and has been associated with a plethora of possible etiological factors. As such, it hasExpand
Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder
  • R. Frye
  • Medicine
  • Epilepsy & Behavior
  • 2015
TLDR
An overview of metabolic disorders in the context of ASD is provided and their characteristics, diagnostic testing, and treatment with concentration on mitochondrial disorders are discussed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 340 REFERENCES
Novel and emerging treatments for autism spectrum disorders: a systematic review.
  • D. Rossignol
  • Medicine
  • Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
  • 2009
TLDR
The reviewed treatments for ASD are commonly used, and some are supported by prospective RCTs, while some have adverse effects and further studies exploring these treatments are needed. Expand
Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey
TLDR
A comprehensive on-line seizure survey developed to determine the effectiveness of traditional and non-traditional treatments for improving seizures and influencing other clinical factor relevant to ASD provided information regarding parental perceptions of effectiveness. Expand
New directions in the treatment of autism spectrum disorders from animal model research
TLDR
This review examines what approaches have been used for the drugs that are currently being used to treat people with ASD and two areas in particular, the glutamate and oxytocin systems, provide exciting new avenues for drug discovery. Expand
Autism and social cognition in epilepsy: implications for comprehensive epilepsy care.
  • R. Tuchman
  • Psychology, Medicine
  • Current opinion in neurology
  • 2013
TLDR
There is a significant and important overlap between epilepsy and ASD and this has important implications for comprehensive care of all individuals with epilepsy. Expand
A Review of Complementary and Alternative Treatments for Autism Spectrum Disorders
TLDR
Recommendations for future research and clinical recommendations for practitioners are made about complementary and alternative treatments (CATs) for ASD. Expand
Neurofeedback for Autistic Disorders: Emerging Empirical Evidence
Autism spectrum disorders (ASD) are a group of pervasive developmental disorders impacting communication, social skills, behavioral interests, and daily functioning. With rates rising to as high as 1Expand
Autism: electroencephalogram abnormalities and clinical improvement with valproic acid.
  • A. Plioplys
  • Medicine
  • Archives of pediatrics & adolescent medicine
  • 1994
TLDR
There is little evidence to suggest that seizure-free children with rare spikes or other paroxysmal EEG discharges will benefit from anticonvulsants, and in a recent review of autism, Rapin 5 wrote. Expand
Clinical genetics evaluation in identifying the etiology of autism spectrum disorders: 2013 guideline revisions
TLDR
The guidelines in this paper have been developed to assist the clinician in the consideration of factors and are updates the original publication from 2008. Expand
Screening Electroencephalograms in Autism Spectrum Disorders: Evidence-Based Guideline
TLDR
There is currently insufficient evidence to recommend for or against the use of screening EEGs in autistic patients, and given the frequency of seizure disorders in this patient population, a high index of clinical suspicion should be maintained for subtle symptoms of seizures. Expand
The effects of vagus nerve stimulation therapy on patients with intractable seizures and either Landau–Kleffner syndrome or autism
  • Y. Park
  • Medicine, Psychology
  • Epilepsy & Behavior
  • 2003
TLDR
Preliminary findings are encouraging, but a prospective study using standardized measurement tools specific to these disorders and a longer-term follow-up are necessary to better gauge the efficacy of VNS therapy among these patient populations. Expand
...
1
2
3
4
5
...