A Review of Studies of the Hamilton Depression Rating Scale in Healthy Controls: Implications for the Definition of Remission in Treatment Studies of Depression
@article{Zimmerman2004ARO, title={A Review of Studies of the Hamilton Depression Rating Scale in Healthy Controls: Implications for the Definition of Remission in Treatment Studies of Depression}, author={Mark Zimmerman and Iwona Chelminski and Michael A. Posternak}, journal={The Journal of Nervous and Mental Disease}, year={2004}, volume={192}, pages={595-601} }
The Hamilton Rating Scale for Depression (HRSD) is the most commonly used symptom severity scale to evaluate the efficacy of antidepressant treatment. On the basis of an expert consensus panel, an HRSD score of ≤7 was recommended as a cutoff to define remission. Since that recommendation, little empirical work has been conducted to confirm the validity of this threshold. One approach toward determining a cutoff score for defining remission is to establish the range of values for healthy…
128 Citations
Is the Cutoff to Define Remission on the Hamilton Rating Scale for Depression Too High?
- PsychologyThe Journal of nervous and mental disease
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The results of the present study support the use of a lower cutoff on the HRSD than has been traditionally used to define remission, and the association between the breadth of the definition of remission and self-report ratings of global psychosocial functioning and quality of life.
A new type of scale for determining remission from depression: the Remission from Depression Questionnaire.
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Is it time to replace the Hamilton Depression Rating Scale as the primary outcome measure in treatment studies of depression?
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It is discussed whether it is time to replace the HRSD as the primary outcome measure in treatment studies of depression.
Reliability of the Hamilton Rating Scale for Depression: A meta-analysis over a period of 49years
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The present report examined the impact of the cut-off score used to define remission on the percentage of depressed outpatients in ongoing treatment who are considered to be in remission, and the association between remission status and psychosocial impairment for different cut-offs.
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It is concluded that the proposed Hamilton Depression Rating Scale cut-off of 0.875 has no scientific basis and is likely misleading; there is no agreed upon way of delineating clinically significant from clinically insignificant and future clinical trials should consider including measures directly reflective of functioning and wellbeing, in addition to measures focused on depression psychopathology.
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The evidence for the empirical validation of Frank et al.
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The findings indicate that the HAM-D is a valid and sensitive clinimetric index, which should not be discarded in view of obsolete and not clinically relevant psychometric criteria.
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The findings indicate that the DSSS is a useful tool for simultaneously, rapidly, and accurately measuring depression and somatic symptoms in clinical practice settings and in consultation fields.
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