A Review of Studies of the Hamilton Depression Rating Scale in Healthy Controls: Implications for the Definition of Remission in Treatment Studies of Depression

@article{Zimmerman2004ARO,
  title={A Review of Studies of the Hamilton Depression Rating Scale in Healthy Controls: Implications for the Definition of Remission in Treatment Studies of Depression},
  author={M. Zimmerman and I. Chelminski and M. Posternak},
  journal={The Journal of Nervous and Mental Disease},
  year={2004},
  volume={192},
  pages={595-601}
}
The Hamilton Rating Scale for Depression (HRSD) is the most commonly used symptom severity scale to evaluate the efficacy of antidepressant treatment. On the basis of an expert consensus panel, an HRSD score of ≤7 was recommended as a cutoff to define remission. Since that recommendation, little empirical work has been conducted to confirm the validity of this threshold. One approach toward determining a cutoff score for defining remission is to establish the range of values for healthy… Expand
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119 Citations
Highly Influential Citations
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Background Citations
26
Methods Citations
25
Results Citations
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119 Citations

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Citation Type

Is the Cutoff to Define Remission on the Hamilton Rating Scale for Depression Too High?
TLDR
The results of the present study support the use of a lower cutoff on the HRSD than has been traditionally used to define remission, and the association between the breadth of the definition of remission and self-report ratings of global psychosocial functioning and quality of life. Expand
A new type of scale for determining remission from depression: the Remission from Depression Questionnaire.
TLDR
The RDQ is a reliable and valid measure that evaluates the multiple domains that depressed patients consider important in determining remission, and is consistent with prior research suggesting that depression patients' perspective of remission goes beyond symptom resolution. Expand
Is it time to replace the Hamilton Depression Rating Scale as the primary outcome measure in treatment studies of depression?
TLDR
It is discussed whether it is time to replace the HRSD as the primary outcome measure in treatment studies of depression. Expand
Reliability of the Hamilton Rating Scale for Depression: A meta-analysis over a period of 49years
TLDR
Figures indicate good overall levels of internal consistency, inter-rater and test-retest reliability, but some HRSD items do not appear to possess a satisfactory reliability. Expand
Implications of using different cut-offs on symptom severity scales to define remission from depression
TLDR
The present report examined the impact of the cut-off score used to define remission on the percentage of depressed outpatients in ongoing treatment who are considered to be in remission, and the association between remission status and psychosocial impairment for different cut-offs. Expand
One (effect) size does not fit at all: Interpreting clinical significance and effect sizes in depression treatment trials
TLDR
It is concluded that the proposed Hamilton Depression Rating Scale cut-off of 0.875 has no scientific basis and is likely misleading; there is no agreed upon way of delineating clinically significant from clinically insignificant and future clinical trials should consider including measures directly reflective of functioning and wellbeing, in addition to measures focused on depression psychopathology. Expand
Empirical evidence for definitions of episode, remission, recovery, relapse and recurrence in depression: a systematic review
TLDR
The evidence for the empirical validation of Frank et al. Expand
The Hamilton Rating Scales for Depression: A Critical Review of Clinimetric Properties of Different Versions
TLDR
The findings indicate that the HAM-D is a valid and sensitive clinimetric index, which should not be discarded in view of obsolete and not clinically relevant psychometric criteria. Expand
Do Somatic Symptoms Predict the Severity of Depression? A Validation Study of the Korean Version of the Depression and Somatic Symptoms Scale
TLDR
The findings indicate that the DSSS is a useful tool for simultaneously, rapidly, and accurately measuring depression and somatic symptoms in clinical practice settings and in consultation fields. Expand
Hamilton depression rating scale: Uses and applications
Abstract The Hamilton Depression Rating Scale is a widely used measuring instrument to assess the severity of depression in dynamics and the effectiveness of treatment of patients with already… Expand
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