A Review of Randomized Clinical Trials in Tinnitus

  title={A Review of Randomized Clinical Trials in Tinnitus},
  author={Robert A Dobie},
  journal={The Laryngoscope},
  • R. Dobie
  • Published 1 August 1999
  • Medicine
  • The Laryngoscope
Objectives: Review reports of randomized clinical trials (RCTs) in tinnitus to identify well‐established treatments, promising developments, and opportunities for improvement in this area of clinical research. 
Systematic review and meta-analyses of randomized controlled trials examining tinnitus management
To evaluate the existing level of evidence for tinnitus management strategies identified in the UK Department of Health's Good Practice Guideline.
Interventions for tinnitus in adults: an overview of systematic reviews
Cochrane ENT decided not to proceed with an overview review at this time, so Protocol withdrawn from Issue 1, 2017 is withdrawn.
[Cognitive behavioural therapy for tinnitus].
This is a protocol for a Cochrane Review (Intervention) to assess the effects and safety of CBT for tinnitus in adults.
Review of pharmacological therapy for tinnitus.
No compelling evidence is found suggesting the efficacy of any pharmacological agent in the treatment of tinnitus, and analysis of prior investigations provides insight to appropriate methods for future work.
A review of alternative treatments for tinnitus
The evidence available from 23 randomised placebo‐controlled trials on the effectiveness of alternative treatments for tinnitus including Ginkgo biloba, acupuncture, laser treatment, ultrasound, ear‐canal magnets, electromagnetic therapy, homeopathy and hypnotherapy is summarized.
The research evidence on the effectiveness of acupuncture for the treatment of pain presented in a recent issue of Effective Health Care is reviewed.
Tinnitus in Context A Contemporary Contextual Behavioral Approach
Tinnitus is the experience of sounds in the ears without any external auditory source and is a common, debilitating, chronic symptom for which we have yet to develop sufficiently efficacious interv
Complementary and integrative treatments: tinnitus.
A Commentary on the Complexity of Tinnitus Management
A counter view is offered on the view that only high-level evidence has a place in forming practice guidelines for tinnitus and the need for strong evidence-based protocols is highlighted.
Sound therapy (using amplification devices and/or sound generators) for tinnitus in adults
This is a protocol for a Cochrane Review (Intervention) to assess the effects of sound therapy (using amplification devices and/or sound generators) for tinnitus in adults.


A Controlled Trial of Acupuncture in Tinnitus
A double-blind cross-over controlled trial of acupuncture and the use of Visual Analogue Scales (V.A.S.) revealed no significant differences between placebo and active acupuncture treatment.
A trial of tinnitus therapy with ear-canal magnets.
A double-blind trial of Takeda's treatment of tinnitus by placing rare-earth magnets close to the tympanic membrane failed to show significant benefit.
Tinnitus: a double-blind crossover controlled trial to evaluate the use of lignocaine.
It is shown that intravenous lignocaine is effective in reducing tinnitus, although duration of such effect is short.
The value of carbamazepine in the treatment of tinnitus.
  • J. H. Hulshof, P. Vermeij
  • Medicine, Psychology
    ORL; journal for oto-rhino-laryngology and its related specialties
  • 1985
A double-blind controlled trial on the use of oral carbamazepine in the treatment of tinnitus and intravenous lidocaine showed less effect than the placebo.
Antidepressant treatment of tinnitus patients: report of a randomized clinical trial and clinical prediction of benefit.
Nortriptyline is useful in some patients with disabling tinnitus, but has not been shown to directly affect tinn Titus sensation, and placebo effects were strongly significant and must be considered important in tinnitis therapy.
Prospective Crossover Evaluation of Four Methods of Clinical Management of Tinnitus
This article summarizes data obtained from 34 tinnitus-afflicted patients who participated in and completed a prospective crossover evaluation of four methods of clinical management of tinn Titus, and respondents' preferences for each method of treatment.
Drug therapy and tinnitus: the UK experience
The finding that three patients with profound hearing losses have had some continued benefit leads to the cautious conclusion that drug responders may be have a central component to their tinnitus.
Benzodiazepines in the treatment of tinnitus
Of all the benzodiazepines studied, only oxazepam and clonazepams were significantly more effective than antihistamines in suppressing chronic tinnitus, but these two drugs alleviated the symptom in 52 per cent and 69 per cent of the individuals treated respectively.
Low-powered ultrasound in the treatment of tinnitus: a pilot study.
Low powered ultrasound was significantly better at producing improvement than placebo (P less than 0.02 Binomial Test) in long standing tinnitus sufferers.
Treatment of tinnitus with intravenous lidocaine: A double-blind randomized trial
  • L. Duckert, T. Rees
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 1983
The results of the study suggest that the clinical usefulness of IV lidocaine in relieving tinnitus may be less than was previously reported.