A Review of Novel Therapies for Melanoma

@article{Karimkhani2014ARO,
  title={A Review of Novel Therapies for Melanoma},
  author={C Karimkhani and R{\'e}n{\'e} Gonzalez and Robert Paul Dellavalle},
  journal={American Journal of Clinical Dermatology},
  year={2014},
  volume={15},
  pages={323-337}
}
This review summarizes results from major recent trials regarding novel therapeutic agents in melanoma. The topics discussed include targeted therapy with BRAF (V-RAF murine sarcoma viral oncogene homolog B) inhibitors (vemurafenib and dabrafenib), MEK (mitogen-activated protein kinase kinase) inhibitors (trametinib), bcr-abl/c-kit/PDGF-R inhibitors (imatinib), and angiogenesis inhibitors (bevacizumab and aflibercept), as well as immunotherapy with anti-CTLA-4 (anti-cytotoxic T-lymphocyte… 
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57 Citations
Highly Influential Citations
2
Background Citations
22
Methods Citations
2

57 Citations

Immune-mediated Adverse Effects of Anti-CTLA-4 Antibody Therapy in Metastatic Melanoma
TLDR
A critical evaluation of the underlying mechanisms of irAEs associated with anti-CTLA-4 therapy is presented and potentially beneficial effects of combinational therapies to alleviate ipilimumab-induced irAES in malignant melanoma are discussed.
Immune-mediated adverse events of anticytotoxic T lymphocyte-associated antigen 4 antibody therapy in metastatic melanoma.
Pembrolizumab: A Review in Advanced Melanoma
TLDR
Pembrolizumab has an acceptable tolerability profile, with immune-related adverse events that are generally manageable/reversible, and is a valuable treatment option for patients with advanced melanoma, including those who have progressed on ipilimumab and BRAF/MEK inhibitors.
Oncolytic Tanapoxvirus for Melanoma Therapy
TLDR
It is demonstrated that IL-2 inhibits virus replication through intracellular components and without activating the interferon-signaling pathway, providing compelling evidence that 15L and/or 66R gene were deleted and that these viruses were generated as a result of double crossover recombination events during transfection and infection.
New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging.
TLDR
A longitudinal study tracks the course of MEKi treatment in an autochthonous imageable murine model of melanoma from initial response to therapeutic resistance, offering new insights into the basis for drug response, persistence, and resistance.
Inhibitor of vasculogenic mimicry restores sensitivity of resistant melanoma cells to DNA-damaging agents
TLDR
Experimental evidence is provided that LCS1269 might be considered as a new potential anticancer agent capable of overcoming multidrug resistance for DNA-damaging agents in melanoma.
Immunovirotherapy with vesicular stomatitis virus and PD-L1 blockade enhances therapeutic outcome in murine acute myeloid leukemia.
TLDR
Overall, the studies show that oncolytic virotherapy combined with immune checkpoint blockade is a promising approach to AML therapy.
Wild-type KRAS is a novel therapeutic target for melanoma contributing to primary and acquired resistance to BRAF inhibition
TLDR
KRASi functions synergistically with BRAF inhibition to reduce melanoma proliferation and to induce apoptosis independently of BRAF mutational status, and acquired resistance to BRAF inhibitors in melanoma is dependent on dynamic regulation of KRAS expression with subsequent AKT and extracellular-signal regulated kinase activation and can be overcome by KRASi.
A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo.
Abl Kinase Regulation by BRAF/ERK and Cooperation with Akt in Melanoma
TLDR
It is demonstrated that BRAFV600E/ERK play a critical role in binding, phosphorylating and regulating Abl localization and Abl/Arg activation by Src family kinases, which has functional and biological significance, driving proliferation, invasion, and switch in epithelial–mesenchymal–transition transcription factor expression.
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