A Review of Novel Therapies for Melanoma

  title={A Review of Novel Therapies for Melanoma},
  author={C. Karimkhani and R. Gonz{\'a}lez and R. Dellavalle},
  journal={American Journal of Clinical Dermatology},
  • C. Karimkhani, R. González, R. Dellavalle
  • Published 2014
  • Medicine
  • American Journal of Clinical Dermatology
  • This review summarizes results from major recent trials regarding novel therapeutic agents in melanoma. The topics discussed include targeted therapy with BRAF (V-RAF murine sarcoma viral oncogene homolog B) inhibitors (vemurafenib and dabrafenib), MEK (mitogen-activated protein kinase kinase) inhibitors (trametinib), bcr-abl/c-kit/PDGF-R inhibitors (imatinib), and angiogenesis inhibitors (bevacizumab and aflibercept), as well as immunotherapy with anti-CTLA-4 (anti-cytotoxic T-lymphocyte… CONTINUE READING
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