A Review of Mouse Models of Monogenic Diabetes and ER Stress Signaling.

@article{Salpea2020ARO,
  title={A Review of Mouse Models of Monogenic Diabetes and ER Stress Signaling.},
  author={Paraskevi Salpea and Cristina Cosentino and Mariana Igoillo-Esteve},
  journal={Methods in molecular biology},
  year={2020},
  volume={2128},
  pages={
          55-67
        }
}
Diabetes is a major public health problem: it is estimated that 420 million people are affected globally. Monogenic forms of diabetes are less common, but variants in monogenic diabetes genes have been shown to contribute to type 2 diabetes risk. In vitro and in vivo models of monogenic forms of diabetes related to the endoplasmic reticulum (ER) stress response provided compelling evidence on the role of ER stress and dysregulated ER stress signaling on β cell demise in type 1 and type 2… 
Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones
TLDR
Findings implicate PWS-imprinted genes in concerted regulation of ER chaperone biosynthesis and β-cell secretory pathway function, illuminating the pathophysiological basis of hormone deficits in PWS.

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