A Review of Evidence Supporting the American Academy of Pediatrics Recommendation for Prescribing Cephalosporin Antibiotics for Penicillin-Allergic Patients

@article{Pichichero2005ARO,
  title={A Review of Evidence Supporting the American Academy of Pediatrics Recommendation for Prescribing Cephalosporin Antibiotics for Penicillin-Allergic Patients},
  author={M. Pichichero},
  journal={Pediatrics},
  year={2005},
  volume={115},
  pages={1048 - 1057}
}
The American Academy of Pediatrics, evidence-based guidelines endorse the use of cephalosporin antibiotics for patients with reported allergies to penicillin, for the treatment of acute bacterial sinusitis and acute otitis media. Many physicians, however, remain reluctant to prescribe such agents. Although such concern is understandable, lack of consistent data regarding exactly what constitutes an initial penicillin-allergic reaction and subsequent cross-sensitivity to cephalosporins may be… Expand
A Review of Evidence Supporting the American Academy of Pediatrics Recommendation for Prescribing Cephalosporin Antibiotics for Penicillin-Allergic Patients
TLDR
There is a low but measurable (0.5%) attributable risk associated with administration of a first-generation or selected second-generation cephalosporin to a patient with penicillin allergy, and this increased risk is not present for third- or fourth- generation cep Halosporins or for second- generation molecules with non–cross-reactive side chains. Expand
The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis.
TLDR
Evidence supporting the use of cephalosporins as a first choice of treatment for many patients with GABHS pharyngitis is examined. Expand
Cephalosporin use in treatment of patients with penicillin allergies.
TLDR
Recent data suggest that the incidence of cross-reactivity among penicillins and cephalosporins is lower than historically reported, and Pharmacists should be aware that cep Halosporin cross- reactivity in a penicillin-allergic patient is not necessarily a class effect. Expand
Evidence Supporting the Use of Cephalosporin Antibiotics in Penicillin-Allergic Patients
TLDR
Based on 38 studies, the evidence suggests that the crossreactive, immunoglobulin E (IgE)-mediated immune responses between penicillins and cephalosporins are based on molecular side chain similarities of the antibiotics rather than similarities in β lactam rings. Expand
The use of cephalosporins in penicillin-allergic patients: a literature review.
TLDR
Overall cross reactivity between penicillins and cephalosporins is lower than previously reported, though there is a strong association between amoxicillin and ampicillin with first- and second-generation cep Halosporin that share a similar R1 side chain. Expand
Misconceptions Surrounding Penicillin Allergy: Implications for Anesthesiologists.
TLDR
A clinical practice algorithm for the perioperative evaluation and management of patients reporting a history of penicillin allergy is presented, concluding that cephalosporins can be safely administered to a majority of such patients. Expand
Management of allergy to penicillins and other beta‐lactams
  • R. Mirakian, S. Leech, +7 authors S. Nasser
  • Medicine
  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2015
TLDR
A guideline for the management of immediate and non‐immediate allergic reactions to penicillins and other beta‐lactams is intended for UK specialists in both adult and paediatric allergy and for other clinicians practising allergy in secondary and tertiary care. Expand
Diagnosis and Management of Immediate Hypersensitivity Reactions to Cephalosporins
TLDR
Skin testing to the cephalosporin in question, using a nonirritating concentration, provides additional information, which can further guide the work-up of a patient suspected of having an allergy to that drug. Expand
Penicillin allergy and surgical prophylaxis: Cephalosporin cross-reactivity risk in a pediatric tertiary care center.
TLDR
The data suggest that the administration of cephalosporins for surgical prophylaxis following induction of anesthesia in a patient with a known or reported penicillin-allergy appears appropriate and results in a lower adverse event rate that when clindamycin is administered. Expand
Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift.
  • M. Pichichero
  • Medicine
  • Diagnostic microbiology and infectious disease
  • 2007
Recent analysis of clinical data and a clearer understanding of the role of chemical structure in the development of cross-reactivity indicate that the increased risk of an allergic reaction toExpand
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