A Review and Update of Mechanisms of Estrogen in the Hippocampus and Amygdala for Anxiety and Depression Behavior

@article{Walf2006ARA,
  title={A Review and Update of Mechanisms of Estrogen in the Hippocampus and Amygdala for Anxiety and Depression Behavior},
  author={Alicia A. Walf and Cheryl Anne Frye},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={1097-1111}
}
Estrogen (E2) has many effects in the central nervous system, including effects on anxiety and depression behavior. This review will address effects of E2 on behaviors related to anxiety and depression in women and animal models and include recent findings from our laboratory related to this topic. E2's antianxiety and antidepressant-like effects may depend upon many factors, including the regimen of E2 utilized and interactions with the hypothalamic–pituitary–adrenal axis. Brain targets for E2… CONTINUE READING
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