A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes

@article{Flemr2013ARD,
  title={A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes},
  author={Maty{\'a}{\vs} Flemr and Radek Mal{\'i}k and Vedran Franke and Jana Nejepinska and Radislav Sedlacek and Kristian Vlahovicek and Petr Svoboda},
  journal={Cell},
  year={2013},
  volume={155},
  pages={807-816}
}
In mammals, a single Dicer participates in biogenesis of small RNAs in microRNA (miRNA) and RNAi pathways. In mice, endogenous RNAi is highly active in oocytes, but not in somatic cells, which we ascribe here to an oocyte-specific Dicer isoform (Dicer(O)). Dicer(O) lacks the N-terminal DExD helicase domain and has higher cleavage activity than the full-length Dicer in somatic cells (Dicer(S)). Unlike Dicer(S), Dicer(O) efficiently produces small RNAs from long double-stranded (dsRNA) substrates… CONTINUE READING
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