A Retrospective Review Assessing the Efficacy and Safety of Nitrofurantoin in Renal Impairment

  title={A Retrospective Review Assessing the Efficacy and Safety of Nitrofurantoin in Renal Impairment},
  author={Ajay Bains and Donna Buna and N. Hoag},
  journal={Canadian Pharmacists Journal / Revue des Pharmaciens du Canada},
  pages={248 - 252}
  • Ajay Bains, Donna Buna, N. Hoag
  • Published 2009
  • Medicine
  • Canadian Pharmacists Journal / Revue des Pharmaciens du Canada
  • Background: Nitrofurantoin (NF) is an antibiotic commonly used to treat uncomplicated urinary tract infections (UTIs). Although NF is contraindicated in patients with an estimated glomerular filtration rate (GFR) of less than 60 mL/min, the evidence demonstrating its lack of efficacy and an increased rate of adverse reactions in these patients is marginal. Methods: A retrospective chart review was conducted to determine the efficacy and safety of NF in patients with a UTI and an estimated GFR… CONTINUE READING
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