A Respiratory Syncytial Virus Vaccine Vectored by a Stable Chimeric and Replication-Deficient Sendai Virus Protects Mice without Inducing Enhanced Disease.

@article{Wiegand2017ARS,
  title={A Respiratory Syncytial Virus Vaccine Vectored by a Stable Chimeric and Replication-Deficient Sendai Virus Protects Mice without Inducing Enhanced Disease.},
  author={Marian Alexander Wiegand and Gianni Gori-Savellini and Claudia Gandolfo and Guido Papa and Christine Kaufmann and Eva Felder and Alessandro Ginori and Maria Giulia Disanto and Donatella Spina and Maria Grazia Cusi},
  journal={Journal of virology},
  year={2017},
  volume={91 10}
}
Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in children and elderly people, and no marketed vaccine exists. In this study, we generated and analyzed a subunit vaccine against RSV based on a novel genome replication-deficient Sendai virus (SeV) vector. We inserted the RSV F protein, known to be a genetically stable antigen, into our vector in a specific way to optimize the vaccine features. By exchanging the ectodomain of the SeV F protein for its… CONTINUE READING

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