A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

@article{Kang1996ARF,
  title={A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity},
  author={H Kang and E. M. Schuman},
  journal={Science},
  year={1996},
  volume={273},
  pages={1402 - 1406}
}
Two neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are able to produce a long-lasting enhancement of synaptic transmission in the hippocampus. Unlike other forms of plasticity, neurotrophin-induced plasticity exhibited an immediate requirement for protein synthesis. Plasticity in rat hippocampal slices in which the synaptic neuropil was isolated from the principal cell bodies also required early protein synthesis. Thus, the neurotrophins may stimulate… Expand
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  • 1999
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