A Replication Study from Chinese Supports Association between Lupus-Risk Allele in TNFSF4 and Renal Disorder

@inproceedings{Zhou2013ARS,
  title={A Replication Study from Chinese Supports Association between Lupus-Risk Allele in TNFSF4 and Renal Disorder},
  author={Xujie Zhou and Fa-juan Cheng and Yuan-yuan Qi and Ming-Hui Zhao and Hong Zhang},
  booktitle={BioMed research international},
  year={2013}
}
A recent phenotypic association study of genetic susceptibility loci in SLE suggested that TNFSF4 gene might be useful to predict renal disorder in lupus patients. To replicate the association, two single-nucleotide polymorphisms (SNPs: rs2205960 and rs10489265) were genotyped in 814 SLE patients. Correlations between genotypes and TNFSF4 expression were determined. The stainings of TNFSF4 in renal biopsy specimens were checked by immunohistochemistry. The SNPs of TNFSF4 were associated with… CONTINUE READING

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