A Regulatory Feedback Loop between HIF-1α and PIM2 in HepG2 Cells

Abstract

To survive under hypoxic conditions, cancer cells remodel glucose metabolism to support tumor progression. HIF transcription factor is essential for cellular response to hypoxia. The underlying mechanism how HIF is constitutively activated in cancer cells remains elusive. In the present study, we characterized a regulatory feedback loop between HIF-1α and… (More)
DOI: 10.1371/journal.pone.0088301

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