A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation.

@article{Fields2015ARA,
  title={A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation.},
  author={Alexander P Fields and Edwin H. Rodriguez and Marko Jovanovic and Noam Stern-Ginossar and Brian J. Haas and Philipp Mertins and Raktima Raychowdhury and Nir Hacohen and Steven A. Carr and Nicholas T Ingolia and Aviv Regev and Jonathan S. Weissman},
  journal={Molecular cell},
  year={2015},
  volume={60 5},
  pages={816-827}
}
A fundamental goal of genomics is to identify the complete set of expressed proteins. Automated annotation strategies rely on assumptions about protein-coding sequences (CDSs), e.g., they are conserved, do not overlap, and exceed a minimum length. However, an increasing number of newly discovered proteins violate these rules. Here we present an experimental and analytical framework, based on ribosome profiling and linear regression, for systematic identification and quantification of… CONTINUE READING
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