A Region of the Ryanodine Receptor Critical for Excitation-Contraction Coupling in Skeletal Muscle*

@article{Yamazawa1997ARO,
  title={A Region of the Ryanodine Receptor Critical for Excitation-Contraction Coupling in Skeletal Muscle*},
  author={T. Yamazawa and H. Takeshima and M. Shimuta and M. Iino},
  journal={The Journal of Biological Chemistry},
  year={1997},
  volume={272},
  pages={8161 - 8164}
}
  • T. Yamazawa, H. Takeshima, +1 author M. Iino
  • Published 1997
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Ca2+ release mediated by the ryanodine receptor (RyR) regulates many important cell functions including excitation-contraction (E-C) coupling in skeletal muscle, by which membrane depolarization controls the opening of RyR via the dihydropyridine receptor. Among the three RyR subtypes, RyR-1 mediates skeletal muscle E-C coupling, whereas RyR-2 and RyR-3 cannot substitute for RyR-1. We carried out expression experiments using cultured mutant skeletal myocytes not having intrinsic intracellular… CONTINUE READING
    Membrane topology and membrane retention of the ryanodine receptor calcium release channel
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