A Reduced Rate of In Vivo Dopamine Transporter Binding is Associated with Lower Relative Reinforcing Efficacy of Stimulants

@article{Wee2006ARR,
  title={A Reduced Rate of In Vivo Dopamine Transporter Binding is Associated with Lower Relative Reinforcing Efficacy of Stimulants},
  author={Sunmee Wee and F. Ivy Carroll and William L. Woolverton},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={351-362}
}
A slow onset of action has been hypothesized to weaken the reinforcing effects of drugs. The present study evaluated this hypothesis with slow-onset cocaine analogs, WIN 35428, RTI 31, and RTI 51. When cocaine or a cocaine analog was made available to rhesus monkeys (n=4 or 5) for self-administration under a progressive-ratio (PR) schedule with a 1-h time-out between injections, all the drugs functioned as positive reinforcers. The maximum number of injections was in the order of cocaine>WIN… 
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  • J. Lile
  • Psychology, Medicine
    Experimental and clinical psychopharmacology
  • 2006
TLDR
Evidence is presented to support the conclusion that affinity for dopamine transporters appears to be of critical importance, whereas serotonintransporters seem to serve a modulatory function, and that slow-onset, long-acting monoamine transporter ligands can be expected to have reinforcing effects and therefore abuse liability, which has implications for the use of these drugs as pharmacotherapies.
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