A RasGTP-induced conformational change in C-RAF is essential for accurate molecular recognition.

@article{Hibino2009ARC,
  title={A RasGTP-induced conformational change in C-RAF is essential for accurate molecular recognition.},
  author={Kayo Hibino and Tatsuo Shibata and Toshio Yanagida and Yasushi Sako},
  journal={Biophysical journal},
  year={2009},
  volume={97 5},
  pages={
          1277-87
        }
}
The dysregulation of Ras-RAF signaling is associated with many types of human cancer. However, the kinetic and dynamic features of the mutual molecular recognition of Ras and RAF remain unknown. Here, we developed a technique for imaging single-pair fluorescence resonance energy transfer in living cells, and coupled this technique to single-molecule kinetic analysis to investigate how C-RAF (a subtype of RAF) molecules distinguish the active form of Ras (RasGTP) from the inactive form (RasGDP… CONTINUE READING
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