A RasGAP SH3 Peptide Aptamer Inhibits RasGAP-Aurora Interaction and Induces Caspase-Independent Tumor Cell Death

@article{Pamonsinlapatham2008ARS,
  title={A RasGAP SH3 Peptide Aptamer Inhibits RasGAP-Aurora Interaction and Induces Caspase-Independent Tumor Cell Death},
  author={Perayot Pamonsinlapatham and R{\'e}da Hadj-Slimane and Françoise Raynaud and Marc Bickle and Claudine Corneloup and Audrey Barthelaix and Yves Lepelletier and Perrine Mercier and Matthieu Schapira and J{\'e}r{\^o}me Samson and Anne-Laure Mathieu and Nicolas Hugo and Olivier Moncorg{\'e} and Ivan Mika{\'e}lian and Sylvie Dufour and Christiane Garbay and Pierre Colas},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={R563 - 574}
}
The Ras GTPase-activating protein RasGAP catalyzes the conversion of active GTP-bound Ras into inactive GDP-bound Ras. However, RasGAP also acts as a positive effector of Ras and exerts an anti-apoptotic activity that is independent of its GAP function and that involves its SH3 (Src homology) domain. We used a combinatorial peptide aptamer approach to select a collection of RasGAP SH3 specific ligands. We mapped the peptide aptamer binding sites by performing yeast two-hybrid mating assays… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Peptide aptamer-mediated inhibition of target proteins by sequestration into aggresomes.

The Journal of biological chemistry • 2006
View 3 Excerpts
Highly Influenced

A comparative analysis of perturbations caused by a gene knockout, a dominant negative allele and a set of peptide aptamers

N Abed, M Bickle, B Marie, M Schapira, R Sanjuan-España
Mol Cell Prot • 2007
View 2 Excerpts

Similar Papers

Loading similar papers…