A Rare Transporter Associated with Antigen Processing Polymorphism Overpresented in HLAlow Colon Cancer Reveals the Functional Significance of the Signature Domain in Antigen Processing

@article{Yang2005ART,
  title={A Rare Transporter Associated with Antigen Processing Polymorphism Overpresented in HLAlow Colon Cancer Reveals the Functional Significance of the Signature Domain in Antigen Processing},
  author={Tianyu Yang and Philip Edward Lapinski and Haotian Zhao and Qunmin Zhou and Huiming Zhang and Malini Raghavan and Yang Liu and Pan Zheng},
  journal={Clinical Cancer Research},
  year={2005},
  volume={11},
  pages={3614 - 3623}
}
Transporter associated with antigen processing (TAP), a member of the ATP-binding cassette transporter superfamily, is composed of two integral membrane proteins, TAP-1 and TAP-2. Each subunit has a C-terminal nucleotide-binding domain that binds and hydrolyzes ATP to energize peptide translocation across the endoplasmic reticulum membrane. A motif comprising the sequence LSGGQ (called the signature motif) and the amino acid that is immediately C-terminal to this motif are highly conserved in… 
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TLDR
It is demonstrated biochemically that there are two electrostatic interactions across the interface between the two TAP NBDs and that these interactions are important for peptide transport, suggesting that the interactions function at alternative stages in the transport cycle.
Association of TAP1 and TAP2 gene polymorphisms with hematological malignancies.
TLDR
It could be concluded that the TAP2-665 GG genotype might be a risk factor for all types of hematological malignancies included in this study.
The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter
TLDR
A potential mechanism for the TAP protein is outlined with supporting evidence from bacterial transporter structures and the notion that ABC transporters in general have adapted around a universal transport mechanism is supported.
The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese
TLDR
The genotype of the TAP1 gene is associated with susceptibility to CRC, and a significant trend in the rate of cases was observed with an increasing number of mutated alleles.
HLA-B44 Polymorphisms at Position 116 of the Heavy Chain Influence TAP Complex Binding via an Effect on Peptide Occupancy1
TLDR
These studies suggest that position 116 HLA polymorphisms influence peptide occupancy, which in turn determines binding to tapasin and TAP.
Genetic variation of antigen processing machinery components and association with cervical carcinoma
TLDR
Combined genetic variation in the TAP2, LMP7, and ERAP1 genes is associated with increased cervical carcinoma risk, and SNP genotypes and haplotypes are modeled on disease risk.
Novel insights into the molecular mechanisms of HLA class I abnormalities
  • B. Seliger
  • Biology
    Cancer Immunology, Immunotherapy
  • 2011
TLDR
A direct link between altered transcription factor binding, interferon signal transduction and MHC class I APM component expression has been shown, which will help to design effective T cell-based immunotherapies and give novel insights into the (patho) physiology of the antigen-processing and presenting pathway.
Role of genetic variations on MHC class I antigen-processing genes in human cancer and viral-mediated diseases.
Upregulation of antigen-processing machinery components at mRNA level in acute lymphoblastic leukemia cells after CD40 stimulation
TLDR
Assessment of antigen-processing machinery (APM) components in acute lymphoblastic leukemia (ALL) cells before and after CD40 stimulation at messenger RNA (mRNA) level confirms specific stimulation of the antigen- processing system in ALL cells by CD40L.
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TLDR
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TLDR
A model in which nucleotide and peptide release from TAP are coupled and followed by ATP binding to TAP2, which induces high peptide affinity and initiates the transport cycle is proposed.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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