A Rapid Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Method for Single-Plasmid Tracking in an Outbreak of Carbapenem-Resistant Enterobacteriaceae

@article{Lau2014ARM,
  title={A Rapid Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry-Based Method for Single-Plasmid Tracking in an Outbreak of Carbapenem-Resistant Enterobacteriaceae},
  author={Anna F. Lau and Honghui Wang and Rebecca A. Weingarten and Steven K. Drake and Anthony F. Suffredini and Mark K Garfield and Yong Chen and Marjan Gucek and Jung-Ho Youn and Frida Stock and Hanna Tso and Jim DeLeo and James J. Cimino and Karen M. Frank and John P. Dekker},
  journal={Journal of Clinical Microbiology},
  year={2014},
  volume={52},
  pages={2804 - 2812}
}
ABSTRACT Carbapenem-resistant Enterobacteriaceae (CRE) have spread globally and represent a serious and growing threat to public health. Rapid methods for tracking plasmids carrying carbapenemase genes could greatly benefit infection control efforts. Here, we demonstrate that real-time, direct tracking of a single plasmid in a bacterial strain responsible for an outbreak is possible using a commercial matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS… Expand
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