A Rapid, Robust and Ultra-Sensitive HPLC Enantioseparation of β-Amino Alcohols.

@article{Dubey2015ARR,
  title={A Rapid, Robust and Ultra-Sensitive HPLC Enantioseparation of β-Amino Alcohols.},
  author={R. Dubey and R. Bhushan},
  journal={Journal of chromatographic science},
  year={2015},
  volume={53 8},
  pages={
          1366-72
        }
}
Enantioseparation of amino acid analogues racemic β-amino alcohols has hitherto been thought impossible without prior derivatization. Method developers of chromatographic enantioseparation often face detection challenge due to low ultraviolet (UV) absorbance of these molecules. A new chiral derivatizing reagent, benzimidazole-(S)-naproxen amide, was synthesized to provide UV detectable chiral moiety for detection of respective diastereomers of eight β-amino alcohols (dl-alaninol, dl-leucinol… Expand
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