A Randomized Trial to Assess the Effect of Doravirine on the QTc Interval Using a Single Supratherapeutic Dose in Healthy Adult Volunteers.

@article{Khalilieh2017ART,
  title={A Randomized Trial to Assess the Effect of Doravirine on the QTc Interval Using a Single Supratherapeutic Dose in Healthy Adult Volunteers.},
  author={Sauzanne Khalilieh and Ka Lai Yee and Li Ming Fan and Rachael Liu and Walter Heber and Elise Dunzo and Ilias Triantafyllou and A. Makun Hussaini and Marian Iwamoto},
  journal={Clinical drug investigation},
  year={2017},
  volume={37 10},
  pages={975-984}
}
INTRODUCTION Doravirine is a novel HIV-1 non-nucleoside reverse transcriptase inhibitor exhibiting a robust safety and efficacy profile in combination with other antiretrovirals. While existing data do not suggest that doravirine delays cardiac repolarization, the aim of this trial was to evaluate the effects of a supratherapeutic dose of doravirine on the heart-rate corrected QT (QTc) interval in healthy adults. METHODS A randomized, three-period, crossover, placebo-controlled trial was… CONTINUE READING
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