A Randomized Trial to Assess Anti-HIV Activity in Female Genital Tract Secretions and Soluble Mucosal Immunity Following Application of 1% Tenofovir Gel

@inproceedings{Keller2011ART,
  title={A Randomized Trial to Assess Anti-HIV Activity in Female Genital Tract Secretions and Soluble Mucosal Immunity Following Application of 1% Tenofovir Gel},
  author={Marla J. Keller and Rebecca Pellett Madan and N. Merna Torres and Melissa J. Fazzari and Sylvia Cho and Sabah Kalyoussef and Gail F Shust and Pedro M. M. Mesquita and Nicolette A Louissaint and Jun Chen and Hillel W. Cohen and Erin C. Diament and Arier C. Lee and Lydia E. Soto-Torres and Craig W Hendrix and Betsy C. Herold},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Preclinical and early phase clinical microbicide studies have not consistently predicted the outcome of efficacy trials. To address this gap, candidate biomarkers of microbicide pharmacodynamics and safety were evaluated in a double-blind, placebo-controlled trial of tenofovir gel, the first microbicide to demonstrate significant protection against HIV acquisition. METHODS 30 women were randomized to apply a single daily dose of tenofovir or placebo gel for 14 consecutive days… CONTINUE READING
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