A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis.

@article{Flum2020ART,
  title={A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis.},
  author={David R. Flum and Giana H Davidson and Sarah E Monsell and Nathan I. Shapiro and Stephen R. Odom and Sabrina E. Sanchez and Frederick Thurston Drake and Katherine Fischkoff and Jeffrey Johnson and Joe H. Patton and Heather L. Evans and Joseph Cuschieri and Amber K. Sabbatini and Brett A Faine and D. Skeete and Mike K. Liang and Vance Y. Sohn and Karen McGrane and Matthew E Kutcher and B. Chung and Damien Wilson Carter and Patricia Ayoung-Chee and William K Chiang and Amy P. Rushing and Steven M. Steinberg and Careen S Foster and Shaina M. Schaetzel and Thea P. Price and Katherine A Mandell and Lisa Ferrigno and Matthew Salzberg and Daniel A. Deugarte and Amy H. Kaji and Gregory J. Moran and Darin J. Saltzman and Hasan B Alam and Pauline K Park and Lillian S. Kao and Callie M. Thompson and Wesley H. Self and Julianna T Yu and Abigail Wiebusch and Robert J. Winchell and Sunday Clark and Anusha Krishnadasan and Erin Fannon and Danielle C. Lavallee and Bryan A. Comstock and Bonnie J Bizzell and Patrick J. Heagerty and Larry G. Kessler and David A Talan},
  journal={The New England journal of medicine},
  year={2020}
}
BACKGROUND Antibiotic therapy has been proposed as an alternative to surgery for the treatment of appendicitis. METHODS We conducted a pragmatic, nonblinded, noninferiority, randomized trial comparing antibiotic therapy (10-day course) with appendectomy in patients with appendicitis at 25 U.S. centers. The primary outcome was 30-day health status, as assessed with the European Quality of Life-5 Dimensions (EQ-5D) questionnaire (scores range from 0 to 1, with higher scores indicating better… Expand

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