A Randomized Study of Lubiprostone for Opioid-Induced Constipation in Patients with Chronic Noncancer Pain

@inproceedings{Cryer2014ARS,
  title={A Randomized Study of Lubiprostone for Opioid-Induced Constipation in Patients with Chronic Noncancer Pain},
  author={Byron L. Cryer and Seymour Katz and Ricardo Marin Vallejo and Anca Popescu and Ryuji Ueno},
  booktitle={Pain medicine},
  year={2014}
}
OBJECTIVE To evaluate the efficacy and safety of oral lubiprostone for relieving symptoms of opioid-induced constipation (OIC) in patients with chronic noncancer pain. DESIGN Prospective, randomized, double-blind, placebo-controlled trial. SETTING Seventy-nine US and Canadian centers. SUBJECTS Patients aged ≥ 18 years with OIC, defined as <3 spontaneous bowel movements (SBMs) per week. METHODS Patients received lubiprostone 24 mcg or placebo twice daily for 12 weeks. The primary… CONTINUE READING
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