A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression

@article{Dougherty2015ARS,
  title={A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression},
  author={Darin D. Dougherty and Ali R. Rezai and Linda L. Carpenter and Robert H. Howland and Mahendra T. Bhati and John P O'reardon and Emad N. Eskandar and Gordon Baltuch and Andr{\'e} Dallago Machado and Douglas Kondziolka and Cristina Cusin and Karleyton C. Evans and Lawrence H Price and Karen Jacobs and Mayur Pandya and Timothey C. Denko and Audrey R. Tyrka and Tim Brelje and Thilo Deckersbach and Cynthia S. Kubu and Donald Malone},
  journal={Biological Psychiatry},
  year={2015},
  volume={78},
  pages={240-248}
}
BACKGROUND Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant depression (TRD), including those targeting the ventral capsule/ventral striatum target, have shown encouraging response rates. However, no randomized controlled trials of DBS for TRD have been published. METHODS Thirty patients with TRD participated in a sham-controlled trial of DBS at the ventral capsule/ventral striatum target for TRD. Patients were randomized to active versus sham DBS treatment… Expand
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