A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression

  title={A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression},
  author={Darin D. Dougherty and Ali R. Rezai and Linda L. Carpenter and Robert H. Howland and Mahendra T. Bhati and John P O'reardon and Emad N. Eskandar and Gordon Baltuch and Andr{\'e} Dallago Machado and Douglas Kondziolka and Cristina Cusin and Karleyton C. Evans and Lawrence H Price and Karen Jacobs and Mayur Pandya and Timothey C. Denko and Audrey R. Tyrka and Tim Brelje and Thilo Deckersbach and Cynthia S. Kubu and Donald Malone},
  journal={Biological Psychiatry},
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ACAPS may represent an effective intervention for some patients with chronic, disabling, treatment refractory major depression that has failed to respond to other therapeutic approaches, and the adverse effect burden within this population was modest.
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